DAY ONE
7:45 am Conference Registration & Welcome Coffee
8:50 am Chair’s Opening Remarks
Unlocking the Power of Spatial Biology to Revolutionize Immuno-Oncology
9:00 am Harmonizing Discovery by Bridging Clinical & Computational Experts in Spatial Biology
Synopsis
• Fostering collaboration between clinical and discovery researchers to unlock new spatial biology insights
• Exploring the synergy of wet lab techniques with computational analysis for comprehensive spatial profiling
• Developing strategies for gaining organizational support for spatial biology projects
9:30 am Digital Pathology, Tomorrow’s Solutions Today
Synopsis
- Innovating comprehensive AI-driven ecosystems for various applications through Roche’s Digital Pathology Open Environment
- Committing to supporting companies in their digital workflow journey, adapting to their evolving needs
- Enhancing confidence in analysis, and improved lab efficiency through faster slide access, cost reduction, and faster diagnostics through Roche’s digital technology
10:00 am Molecular Pathology in Preclinical Safety Assessments
Synopsis
• Application of molecular pathology techniques in preclinical safety assessments
• Tissue expression profiling to anticipate and mitigate adverse events, ensuring safer immunotherapy
• Best practices for the development of multiplex immunofluorescence panels and image analysis
10:30 am Speed Networking
Synopsis
Bump elbows with your fellow spatial leaders! This is your opportunity to network and forge new contacts with peers in the industry. Join speed networking to meet a broad spectrum of attendees at the summit, and exchange details to catch up later in the event.
11:00 am Morning Break
11:30 am Empowering Translational Research through Spatial Biology
Synopsis
• Utilizing AI for phase three trails
• Demonstrating the innovative application of computational biology in unlocking translational research mechanisms
• Understanding spatial’s importance in evaluating drug efficacy, particularly with specific patient populations, and harnessing the potential for groundbreaking discoveries
12:00 pm Accelerating spatial biology with COMET™
Synopsis
- Learn how to generate reproducible spatial data with fully automated COMET™ staining and imaging platform
- Explore the cellular microenvironment with HORIZON™, an intuitive and user-friendly software designed for seamless integration with COMET™
- Discover COMET's upcoming spatial multiomics application combining RNAscope® and spatial proteomics on the same tissue section
12:30 pm Lunch Break & Networking
Navigating the Evolution of Spatial Biology to Discover Unparalleled Advancements
1:30 pm Navigating Technology Integration & Platform Selection in Spatial Biology
Synopsis
• Integrating spatial biology technologies and mastering combining strategies for seamless workflows
• Navigating the complexities of platform selection by comparing available options, weighing pros and cons
• Integrating spatial data with non-spatial data for deeper insights
2:00 pm Samples to High-Quality Spatial Insights: Comprehensive Biomarker Strategies to Decipher the Tumor Microenvironment.
Synopsis
Enabling high-confidence insights through robust InSituPlex(R) (ISP) assays and AI-driven image analysis.
Combining assay precision and consistency with flexibility in panel design to accelerate verification of biological hypotheses.
Deploying comprehensive biomarker strategies through validated ISP panels, custom assay development and spatial image analysis
2:30 pm Panel Discussion: Pioneering Advances in Spatial Biology Technologies
Synopsis
• Discovering revolutionary spatial biology technologies, opening new dimensions of research possibilities
• Delving into the nuances of spatial analysis technologies, from bulk analysis to single-cell analysis and special genomics
• Analyzing the strengths and weaknesses of diverse spatial technologies, considering factors such as data quality, costeffectiveness, and interpretability
3:15 pm Afternoon Break & Networking
Catalyzing Portfolio Succ/ess Through Unveiling the Power of Tumor Microenvironment Dynamics
3:45 pm Spatial Biology to Enhance Targeted Therapeutics
Synopsis
Evolution of Precision Medicine
New approaches for biomarker discovery through spatial biology
Applying spatial biology to support ADC development
4:15 pm The CCR4 Antagonist, FLX475, Alters Treg Infiltration & Localization in the Tumor Microenvironment & Improves Clinical Response
Synopsis
• Discovering how FLX475 works and its impact on altering Treg infiltration within the tumor microenvironment
• Exploring how FLX475 influences Treg migration and localization, with a focus on strategies to target the tumor microenvironment for improved therapeutic outcomes
• Uncovering the latest clinical trial results and future directions for utilizing FLX475 to enhance clinical responses in cancer treatment
4:45 pm Leveraging AI-Enabled Spatial Imaging to Power Insights in Immune-Oncology
Synopsis
- Tracking immune cell therapy infiltration in patient-derived tumor organoid co-cultures
- Comparing Visium CytAssist interassay similarity and cellular deconvolution
- Generating super-resolved spatial transcriptomics with deep learning models
5:15 pm Chair’s Closing Remarks
5:30 pm End of Day One
Evening at the Roche Arcade
Synopsis
Join Roche for an arcade evening that promises fun and excitement for all of our attendees! Expect, drinks, canapes Pinball, Giant Jenga, Giant Connect 4, and more. But this event is more than just gaming—it's a chance to cultivate our spatial community. Connect with fellow enthusiasts, expand your network, and forge meaningful connections.